Endocrine Abstracts

Generously supported by IPSEN)-->GH replacement (GHR) in adults has demonstrated to improve body composition, inflammatory cardiovascular biomarkers and quality of life. However, this benefit is uneven, and factors that stratify treatment response are required.According to current guidelines, low IGF-I levels in specific conditions provide strong evidence for GH deficiency (GHD). Nevertheless, normal levels do ...

Objective: To study the differences in the metabolic profile of patients with non-functioning adrenal adenomas (NFA) and autonomous cortisol secretion (ACS).Methods: 143 patients diagnosed of adrenal incidentaloma (AI) between 2010 and 2018 were retrospectively analyzed. AI was defined as an adrenal mass≥1 cm, accidentally discovered by radiologic examination. ACS was confirmed by serum cortisol post-dexamethasone suppression test (Nugent)≥3 ...

Purpose: The aim of this study was to evaluate the sensitivy of contrast-enhanced ultrasound (CEUS) in the detection of pathological parathyroid gland in patients with primary hyperparathyroidism in comparison to the 99m-MIBI-SPECT scintigraphy.Methods: 29 patients consecutive (22 female, 7 male) with biochemically confirmed primary hyperparathyroidism, who underwent preoperative imaging with Technetium 99m-MIBI-SPECT scintigraphy and CEUS and subsequent...

ObjectiveSurgery is the only curative treatment for primary hyperparathyroidism. Minimally invasive parathyroidectomy is superior in terms of cure and complication rates and is less costly than inpatient bilateral cervical exploration. Preoperative localization of parathyroid adenoma by imaging is a requirement for outpatient minimally invasive surgery. One of the most frequently used imaging techniques for parathyroid adenoma localization is Tc99m-sesta...

IntroductionAcromegaly is an uncommon chronic disease with an insidious course. Due to the high morbimortality it causes, its early diagnosis and treatment are priority. The three therapeutic pillars are surgery, pharmacological treatment and radiotherapy, alone or in combination.ObjectivesTo clinically, biochemically and histologically characterize patients with acromegaly under follow-up in a tertiary hospi...

Introduction: Primary aldosteronism (PA) is the most common cause of secondary hypertension. Guidelines recommend a confirmatory test in the majority of suspected cases: oral sodium loading, saline infusion test (SIT), captopril challenge test (CCT), or fludrocortisone suppression test. The SIT and CCT are most commonly used in clinical practice to study autonomous aldosterone secretion.Objectives and Methods: We compared the CCT’s diagnosis perform...

PurposeTo assess the risk of developing hypercortisolism and/or tumor growth in non-functioning adrenal incidentalomas (NFAIs) during follow-up.MethodsSeven Spanish institutions participated in this retrospective study for patients with AIs. 1097 patients with one or more AIs ≥ 1 cm evaluated by participating physicians between 2013 and 2020 were subject to inclusion. Patients with missing values in the...